Author Guideline

Editorial Evaluation Timeline

All submissions are initially evaluated in depth by the scientific editors. Papers that are not deemed by the editors to be strong candidates for publication will be returned to the authors without detailed review, typically within 3–5 days. Otherwise, manuscripts will be sent to reviewers who have agreed in advance to assess the paper rapidly. The editors will make every effort to reach decisions on these papers within 3–4 weeks of the submission date. If revisions are a condition of publication, editors will carefully evaluate the reviewers' comments and, whenever possible, will provide guidance on the important concerns to be addressed. We generally allow 2 months for revisions and consider only one revised version of the paper. Evaluations of conceptual advance and significance are made based on the literature available on the day of the final decision, not the day of submission. Accepted papers will be published in print within 3 months of acceptance and, in most cases, earlier in print or online. Any major changes after acceptance are subject to review and may delay publication.

Editorial Policies

Manuscripts are considered with the understanding that no part of the work has been published previously in print or electronic format and the paper is not under consideration by another publication or electronic medium. If you have questions about whether posting a manuscript or data that you plan to submit to this journal on an openly available preprint server or poster repository would affect consideration, we encourage you to contact an editor so that we may provide more specific guidance. In many cases, posting will be possible. All in press or submitted works that are pertinent to the manuscript under consideration by the journal (including those cited in the manuscript under consideration) must accompany the submission. Related manuscripts that have been submitted elsewhere during the period of revision must accompany revised manuscripts. Failure to provide copies of related manuscripts under consideration elsewhere may delay the review process and may be grounds for rejection. Under no circumstances will any paper be considered that contains any data that have been submitted for publication elsewhere.


Corresponding Author: The corresponding author(s) is responsible for ensuring that all appropriate contributors are listed as authors and that all authors have agreed to the manuscript's content and its submission to Science Insights Material & Chemistry. In a case where we become aware of an authorship dispute, authorship must be approved in writing by all of the parties. The corresponding author(s) is also responsible for ensuring adherence to all editorial and submission policies and for any communications and actions that may be necessary after publication. Because of the responsibilities associated with this designation, a maximum of two corresponding authors is allowed. Exceptions will only be considered in cases of compelling need and by prior discussion with the handling editor.

Co-authorship Designations: In recognition of increasingly collaborative studies, up to two additional co-senior authors may be designated. All co-senior authors will be identified by a numeric footnote in the affiliations list, e.g., "5Co-senior author". Beyond co-senior and corresponding author designations (see above), co-authorship designations are only permitted for the first author position. There is no limitation on the number of authors that can be designated as co-first authors, but a description of each author's specific contribution must be provided in the Author Contributions section of the manuscript. All co-first authors will be identified by a numeric footnote in the affiliations list, e.g., "4Co-first author".

As the complexity and interdisciplinary nature of science grows and evolves, so do the networks of collaborations both within and between labs for published articles. While the author list at the start of a manuscript is not an appropriate or sufficient place to convey this increasingly complex information, all authors are encouraged to include the detailed information about the specific contributions of each author and laboratory in the Author Contributions section. For more information, please see "Author Contributions" under "Preparation of Specific Sections."

Conflict of Interest

Science Insights Material & Chemistry requires all authors to disclose any financial conflict of interest that might be construed to influence the results or interpretation of their manuscript. Authors must declare any such conflict in the cover letter accompanying the manuscript and in the Acknowledgments section of the manuscript itself. The corresponding author will be asked to sign a form on behalf of all of the authors regarding potential conflicts of interest at the time of acceptance. As a guideline, any affiliation associated with a payment or financial benefit exceeding $10,000 p.a. or 5% ownership of a company or research funding by a company with related interests would constitute a conflict that must be declared. This policy applies to all submitted research manuscripts and review material. Examples of statement language include: "AUTHOR is an employee and shareholder of COMPANY"; "AUTHOR is a founder of COMPANY and a member of its scientific advisory board"; "This work was supported in part by a grant from COMPANY."

Studies Involving Humans and Animals

For manuscripts reporting studies involving human subjects, statements identifying the committee approving the studies and confirming that informed consent was obtained from all subjects must appear in the Experimental Procedures section. All experiments on live vertebrates or higher invertebrates must be performed in accordance with relevant institutional and national guidelines and regulations. In the manuscript, a statement identifying the committee approving the experiments and confirming that all experiments conform to the relevant regulatory standards must be included in the Experimental Procedures section. The editors reserve the right to seek comments from reviewers or additional information from authors on any cases in which concerns arise. We suggest that researchers carrying out experiments with animals refer to the ARRIVE guidelines and recommendations from an NIH-sponsored workshop regarding experimental design and reporting standards.

Data Processing Policy

Authors should make every attempt to reduce the amount of postacquisition processing of data. Some degree of processing may be unavoidable in certain instances and is permitted provided that the final data accurately reflect that of the original. In the case of image processing, alterations must be applied to the entire image (e.g., brightness, contrast, color balance). In rare instances for which this is not possible (e.g., alterations to a single color channel on a microscopy image), any alterations must be clearly stated in the figure legend and in the Experimental Procedures section. Groupings and consolidation of data (e.g., cropping of images or removal of lanes from gels and blots) must be made apparent and should be explicitly indicated in the appropriate figure legends. Data comparisons should only be made from comparative experiments, and individual data should not be utilized across multiple figures. In cases in which data are used multiple times (e.g., multiple experiments were performed simultaneously with a single control experiment), this must be clearly stated within each figure legend. In the event that it is deemed necessary for proper evaluation of the manuscript, authors will be required to make the original unprocessed data available to the editors of the journal. All accepted manuscripts will be taken through a data presentation image screening process before publication.

Chemical Compounds

If a paper reports new chemical entities, the authors are required to provide the exact structures of the compounds and are encouraged to include appropriate data to support the assignment of each chemical structure reported according to set standards in the field. Papers reporting the synthesis of new molecules must include the details of the synthesis in the Experimental Procedures. We encourage authors to submit their small-molecule crystallographic data to Cambridge Structural Database (CSD) and to deposit all appropriate information to PubChem. In both cases, appropriate database IDs should be included in the final version of the manuscript.

When a paper reports a new chemical entity or use of a known compound, the authors should use systematic nomenclature to refer to the chemical compounds, based on the guidelines of the International Union of Pure and Applied Chemistry (IUPAC). Use of informal common names, such as rapamycin, cholesterol, and penicillin, is also acceptable. Any standard or unconventional abbreviation should be defined at the point where it first occurs in the text.

For graphical representation of chemical structures, we suggest that authors refer to the IUPAC recommendations. There are a range of available molecular editor programs for creating images of chemical structures. Regardless of the program used, when inserting chemical structures into figures and/or tables, please ensure that they are exported from the molecular editor program as high-resolution files.

Distribution of Materials and Data

One of the terms and conditions of publishing with Cell Press is that authors be willing to distribute any materials and protocols used in the published experiments to qualified researchers for their own use. Materials include but are not limited to cells, DNA, antibodies, reagents, organisms, and mouse strains or, if necessary, the relevant ES cells. These must be made available with minimal restrictions and in a timely manner, but it is acceptable to request reasonable payment to cover the cost of maintenance and transport of materials. If there are restrictions to the availability of any materials, data, or information, these must be disclosed in the cover letter and in the Experimental Procedures section of the manuscript at the time of submission.

Data sets must be made freely available to readers from the date of publication and must be provided to editors and peer reviewers at submission for the purposes of evaluating the manuscript.

For the following types of data, submission of the full data set to a community-endorsed, public repository is mandatory. Accession numbers must be provided in the paper. Examples of appropriate public repositories are listed below.

DNA and Protein Sequences

Protein Sequences: Uniprot

DNA and RNA Sequences: Genbank/European Nucleotide Archive (ENA)/DDBJProtein DataBankUniProt

DNA Sequencing Data (traces and short reads): NCBI Trace and Short-Read ArchiveENA's Sequence Read Archive

Deep Sequencing Data: Deposit in GEO or ArrayExpress upon submission to the journal

The sequences of all RNAi, antisense, and morpholino probes must be included in the paper or deposited in a public database with the accession number provided in the paper.

Human genomic data reporting newly described SNPs and CNVs identified in control samples should be deposited in an appropriate repository such as dbSNPthe Database of Genomic Variants Archive (DGVa), or the Database of Genomic Structural Variation (dbVAR).

We encourage but do not require the deposition of human sequence data in an appropriate repository such as dbGaP. We expect that, if data collected for a published paper cannot be included in the paper or made accessible in a public repository, then authors will accommodate legitimate requests for sharing of human genetics data provided that there are no IRB restrictions.

Structures of Biological Macromolecules

The atomic coordinates and related experimental data (structure factor amplitudes/intensities and/or NMR restraints) must be deposited at a member site of the Worldwide Protein Data Bank. Electron microscopy-derived density maps must be deposited into the EMDB through one of the partner sites (Protein Data Bank in Europe or EMDataBank). Atomic coordinates fitted to EM maps must also be deposited to a wwPDB member site. The corresponding database IDs must be included in the manuscript. Authors must agree to release the atomic coordinates and experimental data when the associated article is published. Additionally, Cell Press now recommends that authors include the PDB validation report as part of the Supplemental Information for all new submissions describing results of X-ray and NMR structure determination.

Microarray Data

MIAME-Compliant Microarray Data: GEO or ArrayExpress upon submission to the journal

Data must be MIAME compliant, as described at the MGED website specifying microarray standards.

Other Data Sets

In addition to the information that must be deposited in public databases as detailed above, authors are encouraged to contribute additional information to the appropriate databases. Authors are also encouraged to deposit materials used in their studies in the appropriate repositories for distribution to researchers.

Examples of repositories that facilitate sharing large data sets, including some that offer the option of anonymous referee access to data before publication, include:

For proteomics data: PRIDEPeptideAtlas

For protein interaction data: IMEx consortium of databases, including DIP, IntAct, and MINT

For chemical compound screening and assay data: PubChem

Where there is no public repository and if the data sets are too large to submit to the journal online, authors should either consult the journal editorial office for advice or provide five separate copies of these data to the editors in an appropriate format (for example, CD or DVD) for the purposes of peer review.

Funding Bodies

In compliance with the public access policies of NIH, HHMI, Wellcome Trust, and several other funding bodies, Cell Press deposits accepted, peer-reviewed manuscripts on authors' behalf to PubMed Central (PMC).

Prepublication Publicity

Work intended for submission to Science Insights Material & Chemistry, currently under consideration at a Insights Publisher journal, or in press at a Insights Publisher journal may not be discussed with the media before publication. All Insights Publisher papers will remain under media embargo until 12 PM NOON (US, EST) on their date of publication. Providing preprints, granting interviews, discussing data with members of the media, or participating in press conferences in advance of online publication without prior approval from the Insights Publisher editorial office may be grounds for rejection. With regards to the scientific literature, papers in press with a Insights Publisher journal should not be discussed in reviews elsewhere prior to the date of online publication. Authors are welcome to present and discuss material intended for publication with Insights Publisher at scientific meetings; however, we do require that they refrain from discussing the findings with members of the press beyond those included in the formal presentation. In addition, we encourage meeting organizers to contact our editorial office in advance of a meeting if they have any questions regarding this policy.

Interaction with Members of the Press for Papers in Press

Authors are free to talk with the press one week prior to online publication, provided any information exchanged is embargoed until 12 PM NOON (US, EST) on the day of online publication. Authors may also discuss their work in press under embargo with other scientific journals for purposes of coverage in review material. Please refer any inquiries from media contacts and other journals to us. If your institutional press office wishes to issue a press release, they should contact us in advance for final embargo information.